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Journal Articles

Bhattacharya, S., Read, B., McGovern, E., da Silva, O. High-volume surfactant administration using a minimally invasive technique: Experience from a Canadian Neonatal Intensive Care unit. Paediatr Child Health 2018, 1-5. Available at:

Blood, A. Peridosing Effects of Surfactant Adminisration: Treating the Lung Without Harming the Brain [PowerPoint Slides]. Available at:

Cassidy, K. J., Bull, J. L., Glucksberg, M. R., Dawson, C. A., Haworth, S. T., Hirschl, R., Gavriely, N., Grotberg, J. B. A rat lung model of instilled liquid transport in the pulmonary airways.  J Appl Physiol 2001;90:1955-1967. Available at:

Espinosa, F.F., Kamm, R.D. Bolus dispersal through the lungs in surfactant replacement therapy. J Appl Physiol 1999;86:391-410. Available at:

Espinosa, F.F., Kamm, R.D. Meniscus formation during tracheal instillation of surfactant. J Appl Physiol 1998;85:266-272. Available at:

Guttentag, S., Foster, C. Update in Surfactant Therapy. NeoReviews V. 12 No. 11 November 2011:625-633. Available at:

Hentschel, R., Brune, T., Franke, N., Harms, E., Jorch, G., Sequential changes in compliance and resistance after bolus administration or slow infusion of surfactant in preterm infants. Intensive Care Med 2002;28:622-628. Available at:

Lam BBC, Ng YK, Wong KY. Randomized trial comparing two natural surfactants (Survanta vs. bLES) for treatment of neonatal respiratory distress syndrome. Pediatr Pulmonol. 2005 Jan;39(1):64-9. Available at:

Lemyre B, Lacaze-Masmonteil T, Shah PS, Bodani J, Doucette S, Dunn M, et al. Poractant alfa versus bovine lipid extract surfactant: Prospective Comparative Effectiveness Study. Journal of Perinatology. 2022

Lewis, J. F., Goffin, J., Yue, P., McCaig, L. A., Bjarneson, D., Veldhuizen, R. A. Evaluation of exogenous surfactant treatment strategies in an adult model of acute lung injury. J Appl Physiol 1996;80:1156-64. Available at:

Metcalfe, I. L., Pototschnik, R., Burgoyne, R., Enhorning, G. Lung expansion and survival in rabbit neonates treated with surfactant extract. J. Appl Physiol 1982;53(4):838-43. Available at:

Nouraeyan N, Lambrinakos-Raymond A, Leone M, Sant’Anna G. Surfactant administration in neonates: A review of delivery methods. Can J Respir Ther. 2014 Fall; 50(3):91-5.
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Rubin, B.K., Ramirez, O., King, M. Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy. Chest. 101;1080-1085, 1992. Available at:

Seshia, M., Ethawi, Y. A., Hussain, A., Minski, J., Miller, J., Alvaro, R. Large volume surfactant administration in preterm infants using minimally invasive technique (ECALMIST; Early CPAP and Large Volume Minimal Invasive Surfactant Therapy). 2012. Abstract – ECALMIST

Stockley, E., Valotaire, R., Miller, M., da Silva, O. Effects of bovine lipid extract surfactant administration in preterm infants treated for respiratory distress syndrome. Health Sci Rep. 2018;e34. Available at:

Ueda, T., Ikegami, M., Rider, E. D., Jobe, A. H. Distribution of surfactant and ventilation in surfactant-treated preterm lambs. J. Appl. Physiol. 76(1):45-55, 1994. Available at: