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Journal Articles

Bhattacharya, S., Read, B., McGovern, E., da Silva, O. High-volume surfactant administration using a minimally invasive technique: Experience from a Canadian Neonatal Intensive Care unit. Paediatr Child Health 2018, 1-5. Available at:

Blood, A. Peridosing Effects of Surfactant Adminisration: Treating the Lung Without Harming the Brain [PowerPoint Slides]. Available at:

Cassidy, K. J., Bull, J. L., Glucksberg, M. R., Dawson, C. A., Haworth, S. T., Hirschl, R., Gavriely, N., Grotberg, J. B. A rat lung model of instilled liquid transport in the pulmonary airways.  J Appl Physiol 2001;90:1955-1967. Available at:

Espinosa, F.F., Kamm, R.D. Bolus dispersal through the lungs in surfactant replacement therapy. J Appl Physiol 1999;86:391-410. Available at:

Espinosa, F.F., Kamm, R.D. Meniscus formation during tracheal instillation of surfactant. J Appl Physiol 1998;85:266-272. Available at:

Guttentag, S., Foster, C. Update in Surfactant Therapy. NeoReviews V. 12 No. 11 November 2011:625-633. Available at:

Hentschel, R., Brune, T., Franke, N., Harms, E., Jorch, G., Sequential changes in compliance and resistance after bolus administration or slow infusion of surfactant in preterm infants. Intensive Care Med 2002;28:622-628. Available at:

Lam BBC, Ng YK, Wong KY. Randomized trial comparing two natural surfactants (Survanta vs. bLES) for treatment of neonatal respiratory distress syndrome. Pediatr Pulmonol. 2005 Jan;39(1):64-9. Available at:

Lewis, J. F., Goffin, J., Yue, P., McCaig, L. A., Bjarneson, D., Veldhuizen, R. A. Evaluation of exogenous surfactant treatment strategies in an adult model of acute lung injury. J Appl Physiol 1996;80:1156-64. Available at:

Metcalfe, I. L., Pototschnik, R., Burgoyne, R., Enhorning, G. Lung expansion and survival in rabbit neonates treated with surfactant extract. J. Appl Physiol 1982;53(4):838-43. Available at:

Nouraeyan N, Lambrinakos-Raymond A, Leone M, Sant’Anna G. Surfactant administration in neonates: A review of delivery methods. Can J Respir Ther. 2014 Fall; 50(3):91-5.
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Rubin, B.K., Ramirez, O., King, M. Mucus rheology and transport in neonatal respiratory distress syndrome and the effect of surfactant therapy. Chest. 101;1080-1085, 1992. Available at:

Seshia, M., Ethawi, Y. A., Hussain, A., Minski, J., Miller, J., Alvaro, R. Large volume surfactant administration in preterm infants using minimally invasive technique (ECALMIST; Early CPAP and Large Volume Minimal Invasive Surfactant Therapy). 2012. Abstract – ECALMIST

Stockley, E., Valotaire, R., Miller, M., da Silva, O. Effects of bovine lipid extract surfactant administration in preterm infants treated for respiratory distress syndrome. Health Sci Rep. 2018;e34. Available at:

Ueda, T., Ikegami, M., Rider, E. D., Jobe, A. H. Distribution of surfactant and ventilation in surfactant-treated preterm lambs. J. Appl. Physiol. 76(1):45-55, 1994. Available at: